Kinetic Study of a 2‐Hydroxypropyl‐β‐Cyclodextrin‐Based Formulation of all‐trans‐Retinoic Acid in Sprague‐Dawley Rats After Oral or Intravenous Administration

2000 ◽  
Vol 89 (2) ◽  
pp. 260-267 ◽  
Author(s):  
Hai‐Shu Lin ◽  
Sui Yung Chan ◽  
Kerwin Siew Yang Low ◽  
Mei Leng Shoon ◽  
Paul C. Ho
Keyword(s):  
Retinoic Acid ◽  
Kinetic Study ◽  
Intravenous Administration ◽  
Sprague Dawley ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Sprague Dawley Rats

Effects of Subcutaneously Injected Graded Doses of All-Trans Retinoic Acid and All-Trans Retinoyl beta-Glucuronide on the Outcome of Pregnancy in Sprague-Dawley Rats

2002 ◽  
Vol 72 (4) ◽  
pp. 229-235 ◽  
Author(s):  
Amanda Ueltschy ◽  
Desiree Gunning ◽  
Arun Barua ◽  
James Olson
Keyword(s):  
Body Weight ◽  
Retinoic Acid ◽  
Equivalent Amount ◽  
Sprague Dawley ◽  
Subcutaneous Injections ◽  
Live Births ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Sprague Dawley Rats ◽  
Dose Levels

The effects of single subcutaneous injections (sc) of graded doses (20, 40, 80, 160, 320, and 480 mumol/kg body weight (BW) of all-trans retinoic acid (RA) and all-trans retinoyl beta-glucuronide (RAG) on day 8.5 of gestation on the outcome of pregnancy in Sprague-Dawley rats was studied. At dose levels of 20, 40, and 80 mumol/kg BW, neither RA nor RAG showed any adverse maternal or fetal effects. However, at dose levels of 160, 320, and 480 mumol/kg, RA was found to be much more toxic than RAG to both mother and fetus. Fetuses of animals receiving a 160 mumol/ kg BW dose of RA were significantly reduced in weight and length, while animals receiving the same dose of RAG had fetuses of normal size. RA doses of 320 and 480 mumol/ kg BW resulted in symptoms of maternal toxicity and even death. In contrast, RAG at these high levels produced no signs of maternal toxicity. RAG doses of 320 and 480 mumol/ kg BW were also less toxic to fetuses. RA doses of 320 mumol/kg BW resulted in only 8% live births, while animals treated with an equivalent amount of RAG experienced 95% live births. Animals receiving a dose of 480 mumol/kg BW of RA had no live births, but similar doses of RAG resulted in 28% live births and pups of normal size.

Effects of early gestational all-trans retinoic acid treatment on motor skills: A longitudinal study in the offspring of Sprague–Dawley rats

2008 ◽  
Vol 29 (6) ◽  
pp. 1107-1113 ◽  
Author(s):  
Addolorata Coluccia ◽  
Pietro Borracci ◽  
Domenico Belfiore ◽  
Giuseppe Renna ◽  
Arcangela Giustino ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Longitudinal Study ◽  
Motor Skills ◽  
Acid Treatment ◽  
Sprague Dawley ◽  
Retinoic Acid Treatment ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Sprague Dawley Rats

Biodistribution characteristics of all-trans retinoic acid incorporated in liposomes and polymeric micelles following intravenous administration

2005 ◽  
Vol 94 (12) ◽  
pp. 2606-2615 ◽  
Author(s):  
Shigeru Kawakami ◽  
Praneet Opanasopit ◽  
Masayuki Yokoyama ◽  
Narin Chansri ◽  
Tatsuhiro Yamamoto ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Intravenous Administration ◽  
Polymeric Micelles ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals All-trans-retinoic acid distribution and metabolism in vitamin A-marginal rats

2006 ◽  
Vol 291 (2) ◽  
pp. G195-G202 ◽  
Author(s):  
Christopher J. Cifelli ◽  
A. Catharine Ross
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Aqueous Phase ◽  
Solid Phase ◽  
Organ Distribution ◽  
Sprague Dawley ◽  
Disease States ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Plasma Retinol

Retinoids, including all- trans-retinoic acid (RA), are considered to have anti-inflammatory properties and are used therapeutically for diseases of the skin and certain cancers. However, few studies have addressed the effects of disease states on RA metabolism. The present study was conducted to better understand the effects of exogenous RA, both in the absence and presence of inflammation, on the distribution and metabolism of a dose of [3H]RA. Female Sprague-Dawley rats fed a low vitamin A diet were pretreated with RA (po), a low dose of lipopolysaccharide (LPS, ip), or their combination. Twelve hours later, albumin-bound [3H]RA was injected intravenously, and tissue organic- and aqueous-phase3H was determined after 10 and 30 min. In liver and plasma,3H-labeled organic metabolites (e.g., 4-oxo- and 4-hydroxy-RA) were isolated by solid-phase extraction. LPS-induced inflammation significantly reduced plasma retinol by 47%, increased total3H in plasma at 10 min, and reduced total3H in liver at both times. In contrast, RA pretreatment did not affect plasma retinol, significantly increased total3H in plasma at both times, and did not affect liver total3H. However, by 30 min, RA significantly increased [3H]RA metabolism in plasma, liver, lung, and small intestine, as indicated by greater3H-labeled aqueous-phase and3H-labeled organic-phase metabolites. The results presented here demonstrate that, although LPS-induced inflammation affects the organ distribution of RA, the ability of RA to induce its own catabolism is maintained during inflammation. Thus we conclude that RA and LPS act independently to alter RA metabolism in vitamin A-marginal rats.

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